| Role | Voice Part | Classification |
|---|---|---|
| Xerxes (Serse) | Mezzo-Soprano (Tenor) | L |
| Romilda | Soprano | L |
| Arsamenes (Arsamene) | Mezzo-Soprano (Tenor) | F |
| Amastiris (Amastre) | Contralto | F |
| Atalante | Soprano | F |
| Ariodates (Ariodate) | Bass | F |
| Elviro | Bass | S |
| Minimum Chorus: 16 | ||
| Divisi: SATB |